Kyzatrex contains testosterone undecanoate 200mg, an oral form of testosterone used for testosterone replacement therapy (TRT) in adult males with confirmed hypogonadism — a condition in which the testes do not produce sufficient testosterone. Kyzatrex offers a convenient oral alternative to injectable or topical testosterone formulations, addressing a long-standing clinical need for effective oral TRT. It is a prescription-only medicine available only following a full clinical assessment and diagnostic confirmation of hypogonadism at PrimeLife.
How It Works
Testosterone undecanoate in Kyzatrex is absorbed from the gastrointestinal tract via the lymphatic system rather than undergoing first-pass liver metabolism, which has historically limited the bioavailability of earlier oral testosterone preparations. To optimise this lymphatic absorption pathway, Kyzatrex must always be taken with a meal containing fat — administration without food significantly reduces absorption and therapeutic effect. Once absorbed, testosterone undecanoate is converted to testosterone in the blood, restoring physiological testosterone levels and addressing the symptoms of hypogonadism including fatigue, reduced libido, mood disturbance, reduced muscle mass, and impaired sexual function.
Why Choose Kyzatrex for TRT
For patients who prefer to avoid injections or daily gel application, Kyzatrex provides a twice-daily oral capsule option that delivers consistent testosterone replacement without needles or the skin-to-skin transfer precautions required with topical gels. The oral route may be particularly suitable for patients who travel frequently, have needle aversion, or find topical gel application inconvenient or impractical for lifestyle reasons.
Kyzatrex allows dose flexibility, as the prescribing clinician can adjust the number of capsules based on monitored serum testosterone levels. Dose titration is conducted over several weeks with regular blood monitoring to confirm that levels remain within the physiological target range, ensuring treatment is individually optimised rather than applying a fixed dose approach across all patients.
Important Note
Kyzatrex is a prescription-only medicine for use in adult males only. It must not be used in women or children. Common side effects include headache, increased haematocrit, hypertension, and acne. Polycythaemia is a recognised risk with testosterone therapy and requires regular haematocrit monitoring. Kyzatrex is contraindicated in males with known or suspected prostate cancer, breast cancer, or serious cardiovascular conditions. Regular blood monitoring including testosterone levels, full blood count, and PSA is required throughout treatment. This medication must only be used as directed by a qualified prescriber as part of a supervised TRT programme at PrimeLife.
